How long had they been traveling from Nazareth?
Couldn’t Joseph have done a better job of planning? Of figuring out where they were going to stay?
In the days of the Internet and smart phones we can’t quite imagine traveling somewhere without at least some idea of where we’re going to stay.
Maybe Joseph assumed there would be room. Maybe Mary’s pregnancy caused their trip to take longer than expected which gave the city time to fill up.
Or maybe the significance is the simple, humble birth of the Savior.
Maybe the significance is that each of us need to make room for Him in our hearts.